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5+ Clubs Open On Wednesday In Prague (2025 Update)

Why wait for the weekend? Jump into Prague's lively Wednesday night. Here are some top clubs you can't miss.

Written by Tereza Nováková

Updated on January 1, 2025

Dream of a wild night in Prague? Want to feel the city's beat, even on a Wednesday? Picture stepping into clubs full of bright neon lights, where music and vibrant scenes carry you into the night.

With our special 2025 guide, we've chosen more than five clubs that offer more than just a night out. They offer an adventure right into the lively heart of Prague, every Wednesday. From deep beats to cool lounges, we've got places for every mood and preference.

Prague's nightlife shines bright all week. Explore places that mix glam with electric vibes, and let yourself go with unbeatable energy. Whether you love dancing or chilling in a lounge, our list is your ticket to an exceptional Wednesday night.

Get ready for something amazing. Dive into our guide to find your perfect spot in Prague this Wednesday.

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Vibrant nightclub scene at M1 Lounge and Club Prague, filled with a lively crowd under blue lights and floating confetti.

Photo credits: M1 Lounge and Club

(4.5)

1. M1 Lounge and Club

What is it? M1 Lounge and Club is Prague's fun spot, alive with the city's vibe. It's where music, energy, and people come together for a night to remember.

Why we love it: M1 Lounge and Club captures the spirit of Prague's nighttime buzz. Bright lights and loud sounds jump-start the fun. It's easy to find and welcoming, bringing together a fun mix of people from everywhere. Here, top DJs play hits and classics, making every moment move you. Whether you like house, R&B, or hip-hop, M1 has it. It’s the spot to jump into the night, meet new folks, and make memories.

Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday

1, Masná 705, 110 00 Prague

A bustling nightclub scene with bright lights and a lively crowd, capturing the vibrant nightlife at Epic Prague.

Photo credits: Epic Prague

(4.4)

2. Epic Prague

What's Epic Prague? Dive into the city's nightlife at Epic Prague for unforgettable nights. Located at Revoluční 1003/3, this spot is buzzing with excitement, mixing chic style with wild moments under bright lights and amazing sounds.

Why we love it: The vibe at Epic Prague is electric, filled with a mix of people that bring it to life. DJs play great music that keeps you dancing all night. Going out here is an adventure. Every beat pumps through you, making every night a new story. Here, we don't just make memories; we're living legends.

Wednesday, Thursday, Friday, Saturday

Revoluční 1003/3, 110 00 Prague

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"Vibrant nightlife atmosphere with glowing Industry sign at a bar with neon Red Bull logo, illuminated shelves of drinks, and cozy purple seating."

Photo credits: INDUSTRY Prague

(4.4)

3. INDUSTRY Prague

What it is: INDUSTRY Prague is the heart of the city's nightlife. Located at Malá Štupartská 3, this club mixes cool modern touches with a rough, industrial feel. Bright neon lights tell you it's time to dance, and the powerful sound system means you feel every beat. It's a thrilling place for music and dance lovers.

Why we love it: At INDUSTRY Prague, it's not just about great music, which includes everything from EDM to new hits and hidden gems. It's also about the people. The club is filled with friendly locals and travelers, people who love to dance, and those trying it out for the first time. Everyone comes together to create a fun, welcoming atmosphere. Each night offers something special: a chance to let loose, fit in, and party until sunrise. You come for the music but stay for the friendship.

Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday

Malá Štupartská 3, 110 00 Prague

Vibrant nightclub scene at MOONCLUB Prague, featuring dancers, lively crowd, and an illuminated bar area.

Photo credits: MOONCLUB

(4.3)

4. MOONCLUB

What is it? MOONCLUB is the place to be in Prague's nightlife. Found at Dlouhá 709/26, it's a music haven in the city's lively night scene.

Why we love it: MOONCLUB shines with its lively vibe and mix of music like house, EDM, hip-hop, and R&B. The club's cool design and lights match the music, giving a full-on party feel. Here, world trendsetters, local party-goers, and visitors come together for unforgettable nights. At MOONCLUB, each beat and move brings something special.

Wednesday, Thursday, Friday, Saturday

Dlouhá 709/26, 110 00 Prague

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Final word

Here's our list of top Prague clubs for epic Wednesday nights. From the lively Club Roxy to the stylish Duplex Restaurant & Club, we've chosen the best spots for an unforgettable night in this beautiful city. Don't let the day stop your fun; in Prague, Wednesday can become an amazing night. We've found the best places so you can jump right into the fun, making sure you don't miss out on Prague's best nightlife. Ready to start? The city's beats are waiting for you. For more great spots and nightlife tips, check our blog. Prague's Wednesday nights are ready to wow you. Let's go!

Nox Difference

Reserve with Nox to get exclusive access to the finest venues and insider tips.

Priority Access

Reserve 2,000+ venues worldwide.

Your Own Concierge

Get custom, curated recommendations.

VIP Experience

Enjoy special service.

Guide

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