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10+ Clubs Open On Thursday In Rome (2025 Update)

Dive into Rome's exciting Thursday night! Check out our best club picks for amazing experiences every weeknight!

Written by Giulia Bianchi

Updated on January 1, 2025

Ever felt the buzz of Rome at night? Picture streets buzzing with life, pulling you towards secret doors. Behind these doors? The most thrilling Thursday nights of your life. This is more than just a night out. It's a deep dive into Rome's luxury nightlife. Every beat and bassline tells a story. We've picked out over 10 top spots for an unforgettable Thursday night in 2025. Fancy rooftop cocktails under the stars? Live music that touches your heart? Or DJ sets that make you dance till morning? Our guide is your key to Rome's hottest places. Move past the usual and dive into Rome's vibrant Thursday club scene. It's a world filled with glam, thrill, and unmatched fun. Ready to see where the night leads? Jump into our guide and see the best of Roman nightlife.

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Vibrant nightclub scene at Art Cafe Rome with patrons celebrating, holding up sparklers and bottles, bathed in moody red and blue lighting.

Photo credits: Art Cafe

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1. Art Cafe

What is it? The Art Cafe is a top spot in Rome for exciting nightlife. It's in the city's heart, known for top-notch clubbing. It's perfect for those looking for luxury, privacy, and fun nights.

Why we love it: It's more than a club. It's a place where important people meet to enjoy exclusive parties. Each visit is special, with themed events that attract famous people and VIPs from around the world. With great DJs playing a mix of music, The Art Cafe makes your nights in Rome unforgettable. It blends the old city's charm with modern vibes, making every moment inside memorable.

Thursday, Friday, Saturday

Viale del Galoppatoio, 197 Rome

Vibrant nightclub scene at Circolo Degli Illuminati in Rome, filled with people dancing under blue lights and modern, artistic decor.

Photo credits: Circolo Degli Illuminati

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2. Circolo Degli Illuminati

What is it? Circolo Degli Illuminati isn't just any nightclub. It's a special spot in Rome where you can enjoy calm drinks, delicious meals, or dance the night away. Located in the heart of Via Giuseppe Libetta, this place is buzzing with energy every day.

Why we love it: It's unique because it's stylish and plays great music, from house to techno, keeping the dance floor packed. It's a welcoming place for everyone, from locals and tourists to famous people and VIPs. Circolo Degli Illuminati offers unforgettable nights in Rome.

Sunday, Thursday, Friday, Saturday

1 Via Giuseppe Libetta, 00154 Rome

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Crowd enjoying a lively night at The Sanctuary Rome with vibrant lights and raised hands, capturing an energetic nightclub scene.

Photo credits: The Sanctuary

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3. The Sanctuary

What is it? In the heart of Rome, The Sanctuary is a special place that feels like Tulum's warmth meets Thailand's charm. It's not just a restaurant; it's a place where life is celebrated. It offers an escape to a world filled with music, wellness, and friendship.

Why we love it: The Sanctuary is a treat for the senses, serving up exciting global flavors with an exotic spin. Its music vibe is unique, featuring DJs and producers from around the world. It's a haven for music lovers. Here, a mix of people – both locals and visitors – come together to share stories, inspire each other, and leave feeling refreshed. It's more than just a visit; it's an experience that feeds the soul.

Sunday, Thursday, Friday, Saturday

4A Via delle Terme di Traiano, 00184 Rome

Vibrant nightclub scene at Room 26 in Rome, with a crowded dance floor illuminated by blue and green lights, and a DJ performing in the center.

Photo credits: Room 26

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4. Room 26

What's up? Check out Room 26 for a wild night in Rome, right in Piazza Guglielmo Marconi. This club rocks with amazing DJs playing the coolest house, hip hop, and techno. They’ve got a super sound system that makes every beat epic.

Why we dig it: It’s more than a place to dance. It’s where new trends pop up and you make friends. Room 26 has all the vibes of Rome’s nightlife - bold, welcoming, and always memorable. Flying solo or rolling with your pals, this place promises a night filled with beats, connections, and the pure fun of getting lost in the music.

Thursday, Friday, Saturday

29/31 Piazza Guglielmo Marconi, 00144 Rome

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Elegant nighttime ambiance at Profumo Spazio Sensoriale nightclub in Rome, featuring a warmly lit bar area surrounded by chic seating and radiant, tree-like decorations.

Photo credits: Profumo Spazio Sensoriale

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5. Profumo Spazio Sensoriale

What is it? Profumo Spazio Sensoriale in Rome is a unique mix of a restaurant, lounge bar, and beautiful flower garden. It's easy to find at Via di Villa Lauchli. You can get there by public transport or car, and there's plenty of parking space.

Why we love it: It's not just any place. Here, you can enjoy Mediterranean dishes and creative cocktails. The garden is full of flowers and perfect for a relaxing walk. It's great for a quiet dinner, a fun night out, or a special event. Everyone, whether they're from here, visiting, or living as expats, feels welcome at Profumo. It's an experience you'll remember.

Sunday, Tuesday, Wednesday, Thursday, Friday, Saturday

1 Via di Villa Lauchli, 00191 Rome

Interior of Jackie O' Rome nightclub, featuring vibrant lights, sleek bar stools, and a shimmering dance floor ready for a night of fun.

Photo credits: Jackie O'

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6. Jackie O'

What is it? Jackie O' is a famous place in Rome that combines a fancy nightclub and a high-end restaurant. It's near the famous streets of Via Vittorio Veneto and Piazza di Spagna, offering a special mix of luxury. The place looks elegant and tells stories of a glamorous past.

Why we love it: Jackie O' has been a top spot for over fifty years, known for its class and charm. It offers live music (Tuesday to Saturday) alongside delicious meals. Every visit is special, making you feel part of a bygone stylish era. It's perfect for private parties or special nights out, like Valentine's Day. Here, you make memories that last.

Tuesday, Wednesday, Thursday, Friday, Saturday

11 Via Boncompagni, 00187 Rome

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A vibrant scene at Alcazar nightclub in Rome with a crowd enjoying a live performance under a glowing disco ball and neon lights.

Photo credits: ALCAZAR

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7. ALCAZAR

What is it? ALCAZAR in Rome is more than just a nightclub. It's a lively mix of music, art, theater, and fine food. It's full of energy, attracting both locals and travelers who want to experience some culture and fun.

Why we love it: ALCAZAR is a treat for all your senses. It has everything from live jazz, art shows, classic movies, to creative food. It's all set in a cool, old cinema. It's perfect for a fun night out or an unforgettable corporate event. ALCAZAR gives you memorable moments that will stick with you.

Sunday, Thursday, Friday, Saturday

14 Via Cardinale Merry del Val, 00153 Rome

Shari Vari Rome

Photo credits: Shari Vari

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8. Shari Vari

What is it? Shari Vari is the go-to spot in Rome for hip hop and electronic music lovers. From Tuesday to Sunday, famous DJs play a mix of classic and new tracks, keeping the dance floor buzzing.

Why we love it: It's more than just the tunes at Shari Vari; it's about the whole vibe. The club has a big dance area and a sleek bar, perfect for any night out. Each room has its own music style, taking you on a world tour of beats. It's where Rome's cool meets dance energy, making every visit special.

Sunday, Tuesday, Wednesday, Thursday, Friday, Saturday

Via di Torre Argentina, 186 Rome

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Final word

In Rome, Thursdays are exciting. The city shows off its fun clubs. We've shared more than ten places perfect for any mood. Whether you're looking for a chill lounge or a dance spot open late, we have you covered. Our guide opens the door to Rome's best nightlife, making sure you know the top spots for fun, luxury, and dance.

Our guide means you're all set for Rome's amazing Thursday night clubs. Now's the time to make memories, getting caught up in the night's energy. But don't stop now—our blog has more travel tips and ideas to make your Rome trip even better. Dive in, explore, and let Rome amaze you. Your next great night out is just a click away!

Nox Difference

Reserve with Nox to get exclusive access to the finest venues and insider tips.

Priority Access

Reserve 2,000+ venues worldwide.

Your Own Concierge

Get custom, curated recommendations.

VIP Experience

Enjoy special service.

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