Photo credits: Jackie O' Rome

5+ Clubs Open On Wednesday In Rome (2025 Update)

Midweek fun: Explore Rome's lively Wednesday nightlife at these cool clubs.

Updated on January 1, 2025

Imagine Rome at night, vibrant and alive, especially on Wednesday. Think of walking through its ancient streets, finding yourself in the heart of Rome's exclusive nightlife. This isn't just any night—it's your ticket to a unique Wednesday party like no other.

Step into a night where every moment is charged with excitement, the music touches your soul, and each drink is a new delight. We're your guide to the best clubs in Rome, places of glamour where unforgettable memories are waiting. Looking for stunning views, famous DJs, or secret spots only locals know? We've got you covered. Join us on this night adventure and transform your Wednesday nights in Rome. Ready to discover what Rome offers after dark? Let's start the journey!

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Vibrant nightclub interior with a stylish bar, colorful lighting, and modern decor at Profumo Spazio Sensoriale in Rome.

Photo credits: Profumo Spazio Sensoriale

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1. Profumo Spazio Sensoriale

What is it? Profumo Spazio Sensoriale is a special place in Rome, on Via di Villa Lauchli. It's not just a nightclub. It's also a restaurant, lounge bar, and event space, all set in a beautiful garden.

Why we love it: Profumo is like a dream with its beautiful flowers and garden. It's perfect for evening walks. The food is full of Mediterranean flavors, and the drinks list has both classic and new cocktails. It's a stylish and relaxing spot, great for a quiet dinner, a romantic date, or a fancy party. Profumo is where you make memories to keep.

Sunday, Tuesday, Wednesday, Thursday, Friday, Saturday

1 Via di Villa Lauchli, 00191 Rome

Elegant dining area at Jackie O' Rome Nightclub, adorned with lush lemon trees overhead, chic black lamps, and pristine white table settings on a plush red carpet.

Photo credits: Jackie O'

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2. Jackie O'

What is it? Step into the heart of Rome at Jackie O'. Experience glamour like never before. It's a top-notch club and restaurant all in one.

Why we love it: Jackie O' is special in Rome. It takes you back to a time of pure elegance. Every bite and every note of music makes it magical. It's more than just a place - it's an unforgettable experience. With menus and spaces for every event, every visit is unique. From amazing Valentine’s Day parties to special evening events, Jackie O’ promises a night full of luxury. Ready for a night full of sophistication? Jackie O’ is waiting.

Tuesday, Wednesday, Thursday, Friday, Saturday

11 Via Boncompagni, 00187 Rome

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Photo credits: Shari Vari

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3. Shari Vari

What is it? Shari Vari in Rome is a cool spot where music meets the city's pulse. It's known for its hip hop and electronic beats. Famous DJs play here, from classic tunes to new hits. It's open six nights a week, with special events and relaxed evenings for drinks with friends.

Why we love it: Shari Vari is not just a club. It's a journey of music. It has a big dance floor and a chic bar. Its rooms reflect the music, inviting you into a beat-driven world. It's not just a night out—it's a trip through the world's sounds, right in Rome's center.

Sunday, Tuesday, Wednesday, Thursday, Friday, Saturday

Via di Torre Argentina, 186 Rome

Final word

Rome shines bright every night, not just on weekends. Our 2025 guide to Wednesday nightclubs opens up the city's party scene. Find chic places with crowds from all over or hidden gems where the music never stops. We've picked the best spots for you. In Rome, every night feels like a party, especially Wednesdays. So, why wait? Jump into Rome's lively nights and make your Wednesday one to remember. Plus, check out our daily guides to keep the fun going, any day you're here.